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Home » Products » Pharmaceutical Bulk Drugs » Azacitidine

Azacitidine

Azacitidine
Azacitidine
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Product Code : 12
Brand Name : AVANSCURE LIFESCIENCES PVT. LTD
Product Description

Leveraging on our rich industry experience, we manufacture, export and supply an excellent quality Azacitidine. The medicine provided by us is processed using quality approved chemical compounds and sophisticated technology under the vigilance of our skilled professionals. Our offered medicine is used in hospitals and nursing homes for the treatment of myelodysplastic syndrome. Apart from that, this Azacitidine is meticulously tested by our quality auditor on well defined parameters to ensure its optimum quality and purity.

DESCRIPTION

Synonyms

Antibiotic U 18496

5-AzaC

Ladakamycin

Mylosar

NSC 102816

NSC 103-627

U 18496

WR 183027

Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes.1 It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitroanti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).2,3,4 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.

TECHNICAL INFORMATION

Formal Name

4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

CAS Number

320-67-2

Synonyms

Antibiotic U 18496

5-AzaC

Ladakamycin

Mylosar

NSC 102816

NSC 103-627

U 18496

WR 183027

Molecular Formula

C8H12N4O5

Formula Weight

244.2

Purity

≥95%

Formulation

A crystalline solid

SMILES

O[C@]1([H])[C@@](O)([H])[C@](CO)([H])O[C@@]1([H])N2C=NC(N)=NC2=O

InChI Code

1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

InChI Key

NMUSYJAQQFHJEW-KVTDHHQDSA-N

 

 

Trade Information
  • Sample Available
  • Yes
  • Sample Policy
  • Contact us for information regarding our sample policy
  • Packaging Details
  • As per buyer requirements
  • Main Export Market(s)
  • Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
  • Main Domestic Market
  • All India

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