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Colistimethate Sodium

Colistimethate Sodium

Product Details:

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Product Description

Colistimethate Sodium is a derived from Colistin and is a cyclic polypeptide antibiotic which belongs to polymyxin group. It is active against Gram-negative bacteria and is used in the treatment of acute infections of Pseudomonas aeruginosa as well as other serious Gram-negative infections.

Colistimethate Sodium is also known as CMS and colistin methanesulfonate sodium.

The drug is given intravenously, but the dosing is complicated. Colistimethate sodium is primarily prescribed in international units (IU), but in cases it is prescribed in milligrams of colistin base as well.

Mode of action

Colistin is polAmikacin Sulfateycationic and has both hydrophilic and lipophilic moieties. These poly-cationic regions interact with the bacterial outer membrane, by displacing bacterial counter ions in the lipopolysaccharide. Hydrophobic/hydrophilic regions interact with the cytoplasmic membrane just like a detergent, solubilizing the membrane in an aqueous environment. This effect is bactericidal even in an isosmolaric environment.

Appearance: White Crystalline Powder

CAS: 8068-37-9

Chemical Name: Colimicina, Colimyscine, Colistin Sulphomethate, CMS and Colistin methanesulfonate sodium

Molecular Formula: C58H105N16Na5O28S5

Molecular Weight: 1634.87

IUPAC Name: [(3-{3-hydroxy-2-[2-(6-methyloctanamido)-4-[(sulfonatomethyl)amino]butanamido]butanamido}-3-{[3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris({2-[(sulfonatomethyl)amino]ethyl})-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)amino]methanesulfonate


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